R. Mark L. Buller, Ph.D.
Professor

Ph.D., Institute of Virology
Glasgow, Scotland, 1976
bullerrm@slu.edu
Publications (1997 to present):

Schaecher SR, Touchette E, Schriewer J, Buller RM, Pekosz A.
The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) gene 7 products contribute to virus-induced apoptosis.
J Virol. 2007 Aug 8;
Pubmed Abstract link: 17686858

Parker S, Nuara A, Buller RM, Schultz DA.
Human monkeypox: an emerging zoonotic disease.
Future Microbiol. 2007 Feb;2:17-34.
Pubmed Abstract link: 17661673

Lawrence SJ, Lottenbach KR, Newman FK, Buller RM, Bellone CJ, Chen JJ, Cohen
GH, Eisenberg RJ, Belshe RB, Stanley SL Jr, Frey SE.
Antibody responses to vaccinia membrane proteins after smallpox vaccination.
J Infect Dis. 2007 Jul 15;196(2):220-9.
Pubmed Abstract link: 17570109

Parker AK, Parker S, Yokoyama WM, Corbett JA, Buller RM.
Induction of natural killer cell responses by ectromelia virus controls
infection.
J Virol. 2007 Apr;81(8):4070-9.
Pubmed Abstract link: 17287257

Sakala IG, Chaudhri G, Buller RM, Nuara AA, Bai H, Chen N, Karupiah G.
Poxvirus-encoded gamma interferon binding protein dampens the host immune
response to infection.
J Virol. 2007 Apr;81(7):3346-53.
Pubmed Abstract link: 17229697

Nuara AA, Buller RM, Bai H.
Identification of residues in the ectromelia virus gamma interferon-binding
protein involved in expanded species specificity.
J Gen Virol. 2007 Jan;88(Pt 1):51-60.
Pubmed Abstract link: 17170436

Hamilton MD, Nuara AA, Gammon DB, Buller RM, Evans DH.
Duplex strand joining reactions catalyzed by vaccinia virus DNA polymerase.
Nucleic Acids Res. 2007;35(1):143-51.
Pubmed Abstract link: 17158165

Hostetler KY, Beadle JR, Trahan J, Aldern KA, Owens G, Schriewer J, Melman L,
Buller RM.
Oral 1-O-octadecyl-2-O-benzyl-sn-glycero-3-cidofovir targets the lung and is
effective against a lethal respiratory challenge with ectromelia virus in mice.
Antiviral Res. 2007 Mar;73(3):212-8.
Pubmed Abstract link: 17123638

Quenelle DC, Buller RM, Parker S, Keith KA, Hruby DE, Jordan R, Kern ER.
Efficacy of delayed treatment with ST-246 given orally against systemic
orthopoxvirus infections in mice.
Antimicrob Agents Chemother. 2007 Feb;51(2):689-95.
Pubmed Abstract link: 17116683

Li G, Chen N, Feng Z, Buller RM, Osborne J, Harms T, Damon I, Upton C,
Esteban DJ.
Genomic sequence and analysis of a vaccinia virus isolate from a patient with a
smallpox vaccine-related complication.
Virol J. 2006 Oct 25;3:88.
Pubmed Abstract link: 17062162

Nuara AA, Bai H, Chen N, Buller RM, Walter MR.
The unique C termini of orthopoxvirus gamma interferon binding proteins are
essential for ligand binding.
J Virol. 2006 Nov;80(21):10675-82.
Pubmed Abstract link: 16928759

Boyle MD, Hess JL, Nuara AA, Buller RM.
Application of immunoproteomics to rapid cytokine detection.
Methods. 2006 Apr;38(4):342-50.
Pubmed Abstract link: 16487723

Liszewski MK, Leung MK, Hauhart R, Buller RM, Bertram P, Wang X, Rosengard
AM, Kotwal GJ, Atkinson JP.
Structure and regulatory profile of the monkeypox inhibitor of complement:
comparison to homologs in vaccinia and variola and evidence for dimer formation.
J Immunol. 2006 Mar 15;176(6):3725-34.
Pubmed Abstract link: 16517741

Empig C, Kenner JR, Perret-Gentil M, Youree BE, Bell E, Chen A, Gurwith M,
Higgins K, Lock M, Rice AD, Schriewer J, Sinangil F, White E, Buller RM, Dermody
TS, Isaacs SN, Moyer RW.
Highly attenuated smallpox vaccine protects rabbits and mice against pathogenic orthopoxvirus challenge.
Vaccine. 2006 Apr 24;24(17):3686-94.
Pubmed Abstract link: 16430997

Li G, Chen N, Roper RL, Feng Z, Hunter A, Danila M, Lefkowitz EJ, Buller RM,
Upton C.
Complete coding sequences of the rabbitpox virus genome.
J Gen Virol. 2005 Nov;86(Pt 11):2969-77.
Pubmed Abstract link: 16227218

Esteban DJ, Buller RM.
Ectromelia virus: the causative agent of mousepox.
J Gen Virol. 2005 Oct;86(Pt 10):2645-59. Review.
Pubmed Abstract link: 16186218

Moran JM, Moxley MA, Buller RM, Corbett JA.
Encephalomyocarditis virus induces PKR-independent mitogen-activated protein kinase activation in macrophages.
J Virol. 2005 Aug;79(16):10226-36.
Pubmed Abstract link: 16051816

Chen N, Li G, Liszewski MK, Atkinson JP, Jahrling PB, Feng Z, Schriewer J,
Buck C, Wang C, Lefkowitz EJ, Esposito JJ, Harms T, Damon IK, Roper RL, Upton C,
Buller RM.
Virulence differences between monkeypox virus isolates from West Africa and the Congo basin.
Virology. 2005 Sep 15;340(1):46-63.
Pubmed Abstract link: 16023693

Moran JM, Buller RM, McHowat J, Turk J, Wohltmann M, Gross RW, Corbett JA.
Genetic and pharmacologic evidence that calcium-independent phospholipase A2beta regulates virus-induced inducible nitric-oxide synthase expression by
macrophages.
J Biol Chem. 2005 Jul 29;280(30):28162-8.
Pubmed Abstract link: 15946940

Bai H, Buller RM, Chen N, Green M, Nuara AA.
Biosynthesis of the IFN-gamma binding protein of ectromelia virus, the causative
agent of mousepox.
Virology. 2005 Mar 30;334(1):41-50.
Pubmed Abstract link: 15749121

Hess JL, Blazer L, Romer T, Faber L, Buller RM, Boyle MD.
Immunoproteomics.
J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 5;815(1-2):65-75.
PubMed abstract link: 15652799

Lefkowitz EJ, Upton C, Changayil SS, Buck C, Traktman P, Buller RM. Poxvirus Bioinformatics Resource Center: a comprehensive Poxviridae informational and analytical resource.
Nucleic Acids Res. 2005 Jan 1;33 Database Issue:D311-6.
PubMed abstract link: 15608205

Huang J, Huang Q, Zhou X, Shen MM, Yen A, Yu SX, Dong G, Qu K, Huang P, Anderson EM, Daniel-Issakani S, Buller RM, Payan DG, Lu HH.
The poxvirus p28 virulence factor is an E3 ubiquitin ligase.
J Biol Chem. 2004 Dec 24;279(52):54110-6.
PubMed abstract link: 15496420

Esteban DJ, Buller RM.
Identification of residues in an orthopoxvirus interleukin-18 binding protein involved in ligand binding and species specificity.
Virology. 2004 Jun 1;323(2):197-207.
PubMed abstract link: 15193916

Chaudhri G, Panchanathan V, Buller RM, van den Eertwegh AJ, Claassen E, Zhou J, de Chazal R, Laman JD, Karupiah G.
Polarized type 1 cytokine response and cell-mediated immunity determine genetic resistance to mousepox.
Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9057-62.
PubMed abstract link: 15184649

Schriewer J, Buller RM, Owens G.
Mouse models for studying orthopoxvirus respiratory infections.
Methods Mol Biol. 2004;269:289-308. Review.
PubMed abstract link: 15114022

Esteban DJ, Nuara AA, Buller RM.
Interleukin-18 and glycosaminoglycan binding by a protein encoded by Variola virus.
J Gen Virol. 2004 May;85(Pt 5):1291-9.
PubMed abstract link: 15105546

Buller RM, Owens G, Schriewer J, Melman L, Beadle JR, Hostetler KY. Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model.
Virology. 2004 Jan 20;318(2):474-81.
PubMed abstract link: 14972516

Chen N, Danila MI, Feng Z, Buller RM, Wang C, Han X, Lefkowitz EJ, Upton C.
The genomic sequence of ectromelia virus, the causative agent of mousepox.
Virology. 2003 Dec 5;317(1):165-86.
PubMed abstract link: 14675635

Maggi LB Jr, Moran JM, Buller RM, Corbett JA.
ERK activation is required for double-stranded RNA- and virus-induced interleukin-1 expression by macrophages.
J Biol Chem. 2003 May 9;278(19):16683-9. Epub 2003 Feb 27.
PubMed abstract link: 12609986

Steer SA, Moran JM, Maggi LB Jr, Buller RM, Perlman H, Corbett JA. Regulation of cyclooxygenase-2 expression by macrophages in response to double-stranded RNA and viral infection.
J Immunol. 2003 Jan 15;170(2):1070-6.
PubMed abstract link: 12517975

Maggi LB Jr, Moran JM, Scarim AL, Ford DA, Yoon JW, McHowat J, Buller RM, Corbett JA.
Novel role for calcium-independent phospholipase A(2) in the macrophage antiviral response of inducible nitric-oxide synthase expression.
J Biol Chem. 2002 Oct 11;277(41):38449-55. Epub 2002 Aug 06.
PubMed abstract link: 12167650

Bai H, Buller RM, Chen N, Boyle MD.
Viral binding proteins as antibody surrogates in immunoassays of cytokines.
Biotechniques. 2002 Jan;32(1):160, 162-4, 166-71.
PubMed abstract link: 11811160

Prejean C, Sarma T, Kurnasov O, Usacheva A, Hemmings B, Cantley L, Fruman DA, Morrison LA, Buller RM, Colamonici OR.
Phosphatidylinositol 3-kinase confers resistance to encephalomyocarditis and herpes simplex virus-induced cell death through the activation of distinct downstream effectors.
J Immunol. 2001 Oct 15;167(8):4553-9.
PubMed abstract link: 11591783

Scarim AL, Arnush M, Blair LA, Concepcion J, Heitmeier MR, Scheuner D, Kaufman RJ, Ryerse J, Buller RM, Corbett JA.
Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis.
Am J Pathol. 2001 Jul;159(1):273-83.
PubMed abstract link: 11438474

Chen N, Baudino T, MacDonald PN, Green M, Kelley WL, Burnett JW, Buller RM.
Selective inhibition of nuclear steroid receptor function by a protein from a human tumorigenic poxvirus.
Virology. 2000 Aug 15;274(1):17-25.
PubMed abstract link: 10936084

Maggi LB Jr, Heitmeier MR, Scheuner D, Kaufman RJ, Buller RM, Corbett JA. Potential role of PKR in double-stranded RNA-induced macrophage activation.
EMBO J. 2000 Jul 17;19(14):3630-8.
PubMed abstract link: 10899117

Chen N, Buller RM, Wall EM, Upton C.
Analysis of host response modifier ORFs of ectromelia virus, the causative agent of mousepox.
Virus Res. 2000 Feb;66(2):155-73.
PubMed abstract link: 10725549

Born TL, Morrison LA, Esteban DJ, VandenBos T, Thebeau LG, Chen N, Spriggs MK, Sims JE, Buller RM. A poxvirus protein that binds to and inactivates IL-18, and inhibits NK cell response.
J Immunol. 2000 Mar 15;164(6):3246-54.
PubMed abstract link: 10706717

Comeau MR, Johnson R, DuBose RF, Petersen M, Gearing P, VandenBos T, Park L, Farrah T, Buller RM, Cohen JI, Strockbine LD, Rauch C, Spriggs MK.
A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR.
Immunity. 1998 Apr;8(4):473-82.
PubMed abstract link: 9586637

Loparev VN, Parsons JM, Knight JC, Panus JF, Ray CA, Buller RM, Pickup DJ, Esposito JJ.
A third distinct tumor necrosis factor receptor of orthopoxviruses.
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3786-91.
PubMed abstract link: 9520445

Wall EM, Cao J, Chen N, Buller RM, Upton C.
A novel poxvirus gene and its human homolog are similar to an E. coli lysophospholipase.
Virus Res. 1997 Dec;52(2):157-67.
PubMed abstract link: 9495531