Recent publications:
Scatizzi JC, Hutcheson J, Bickel E, Haines GK 3rd, Perlman
H.
Pro-apoptotic Bid is required for the resolution of the effector phase of
inflammatory arthritis.
Arthritis Res Ther. 2007 May 17;9(3):R49
Pubmed Abstract link: 17509138
Brunelle JK, Shroff EH, Perlman H, Strasser A, Moraes CT,
Flavell RA, Danial NN, Keith B, Thompson CB, Chandel NS. Loss of Mcl-1 protein
and inhibition of electron transport chain together induce anoxic cell death.
Mol Cell Biol. 2007 Feb;27(4):1222-35. PMID: 17145774
Albee L, Shi B, Perlman H.
Aspartic protease and caspase 3/7 activation are central for macrophage apoptosis
following infection with Escherichia coli.
J Leukoc Biol. 2007 Jan;81(1):229-37.
Pubmed Abstract link: 17023557
Scatizzi JC, Bickel E, Hutcheson J, Haines GK 3rd, Perlman
H.
Bim deficiency leads to exacerbation and prolongation of joint inflammation
in
experimental arthritis.
Arthritis Rheum. 2006 Oct;54(10):3182-93.
Pubmed Abstract link: 17009248
Woods JM, Klosowska K, Spoden DJ, Stumbo NG, Paige DJ, Scatizzi
JC, Volin MV,
Rao MS, Perlman H.
A cell-cycle independent role for p21 in regulating synovial fibroblast migration
in rheumatoid arthritis.
Arthritis Res Ther. 2006;8(4):R113.
Pubmed Abstract link: 16846525
Aprahamian T, Bonegio R, Rizzo J, Perlman H, Lefer DJ, Rifkin
IR, Walsh K.
Simvastatin treatment ameliorates autoimmune disease associated with accelerated
atherosclerosis in a murine lupus model.
J Immunol. 2006 Sep 1;177(5):3028-34.
Pubmed Abstract link: 16920939
Scatizzi JC, Hutcheson J, Bickel E, Woods JM, Klosowska K, Moore TL, Haines
GK
3rd, Perlman H.
p21Cip1 is required for the development of monocytes and their response to
serum transfer-induced arthritis.
Am J Pathol. 2006 May;168(5):1531-41.
Pubmed Abstract link: 16651620
Liu H, Eksarko P, Temkin V, Haines GK 3rd, Perlman H, Koch
AE, Thimmapaya B,
Pope RM.
Mcl-1 is essential for the survival of synovial fibroblasts in rheumatoid
arthritis.
J Immunol. 2005 Dec 15;175(12):8337-45.
Pubmed Abstract link: 16339575
Albee L, Perlman H.
E. coli infection induces caspase dependent degradation of NF-kappaB and reduces
the inflammatory response in macrophages.
Inflamm Res. 2006 Jan;55(1):2-9.
Pubmed Abstract link: 16328105
Hutcheson J, Scatizzi JC, Bickel E, Brown NJ, Bouillet P,
Strasser A, Perlman
H.
Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause
defects in hematopoiesis and in thymocyte apoptosis.
J Exp Med. 2005 Jun 20;201(12):1949-60.
Pubmed Abstract link: 15967824
Brown NJ, Hutcheson J, Bickel E, Scatizzi JC, Albee LD,
Haines GK 3rd, Eslick
J, Bradley K, Taricone E, Perlman H.
Fas death receptor signaling represses monocyte numbers and macrophage activation
in vivo.
J Immunol. 2004 Dec 15;173(12):7584-93.
Pubmed Abstract link: 15585886
Bai S, Liu H, Chen KH, Eksarko P, Perlman H, Moore TL, Pope RM.
NF-kappaB-regulated expression of cellular FLIP protects rheumatoid arthritis
synovial fibroblasts from tumor necrosis factor alpha-mediated apoptosis.
Arthritis Rheum. 2004 Dec;50(12):3844-55.
Eslick J, Scatizzi JC, Albee L, Bickel E, Bradley K, Perlman H.
IL-4 and IL-10 inhibition of spontaneous monocyte apoptosis is associated
with Flip upregulation.
Inflammation. 2004 Jun;28(3):139-45.
Yang J, Sato K, Aprahamian T, Brown NJ, Hutcheson J, Bialik A, Perlman H,
Walsh K.
Endothelial overexpression of Fas ligand decreases atherosclerosis in apolipoprotein
E-deficient mice.
Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1466-73.
Liu H, Ma Y, Pagliari LJ, Perlman H, Yu C, Lin A, Pope RM.
TNF-alpha-induced apoptosis of macrophages following inhibition of NF-kappa
B: a central role for disruption of mitochondria.
J Immunol. 2004 Feb 1;172(3):1907-15.
Bradley K, Scatizzi JC, Fiore S, Shamiyeh E, Koch AE, Firestein GS, Gorges
LL, Kuntsman K, Pope RM, Moore TL, Han J, Perlman H.
Retinoblastoma suppression of matrix metalloproteinase 1, but not interleukin-6,
through a p38-dependent pathway in rheumatoid arthritis synovial fibroblasts.
Arthritis Rheum. 2004 Jan;50(1):78-87.
Perlman H, Nguyen N, Liu H, Eslick J, Esser S, Walsh K, Moore TL, Pope RM.
Rheumatoid arthritis synovial fluid macrophages express decreased tumor necrosis
factor-related apoptosis-inducing ligand R2 and increased decoy receptor tumor
necrosis factor-related apoptosis-inducing ligand R3.
Arthritis Rheum. 2003 Nov;48(11):3096-101.
Yang J, Jones SP, Suhara T, Greer JJ, Ware PD, Nguyen NP, Perlman H, Nelson
DP, Lefer DJ, Walsh K.
Endothelial cell overexpression of fas ligand attenuates ischemia-reperfusion
injury in the heart.
J Biol Chem. 2003 Apr 25;278(17):15185-91. Epub 2003 Feb 07.
Steer SA, Moran JM, Maggi LB Jr, Buller RM, Perlman H, Corbett JA.
Regulation of cyclooxygenase-2 expression by macrophages in response to double-stranded
RNA and viral infection.
J Immunol. 2003 Jan 15;170(2):1070-6.
Perlman H, Bradley K, Liu H, Cole S, Shamiyeh E, Smith RC, Walsh K, Fiore
S, Koch AE, Firestein GS, Haines GK 3rd, Pope RM.
IL-6 and matrix metalloproteinase-1 are regulated by the cyclin-dependent
kinase inhibitor p21 in synovial fibroblasts.
J Immunol. 2003 Jan 15;170(2):838-45.
Perlman H, Liu H, Georganas C, Woods JM, Amin MA, Koch AE, Wickham T, Kovesdi
I, Mano T, Walsh K, Pope RM.
Modifications in adenoviral coat fiber proteins and transcriptional regulatory
sequences enhance transgene expression.
J Rheumatol. 2002 Aug;29(8):1593-600.
Perlman H, Pagliari LJ, Volin MV.
Regulation of apoptosis and cell cycle activity in rheumatoid arthritis. Curr
Mol Med. 2001 Nov;1(5):597-608. Review.
Perlman H, Liu H, Georganas C, Koch AE, Shamiyeh E, Haines GK 3rd, Pope RM.
Differential expression pattern of the antiapoptotic proteins, Bcl-2 and FLIP,
in experimental arthritis.
Arthritis Rheum. 2001 Dec;44(12):2899-908.
Perlman H, Pagliari LJ, Nguyen N, Bradley K, Liu H, Pope RM.
The Fas-FasL death receptor and PI3K pathways independently regulate monocyte
homeostasis.
Eur J Immunol. 2001 Aug;31(8):2421-30.
Liu H, Perlman H, Pagliari LJ, Pope RM.
Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated
macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad,
or caspase activation.
J Exp Med. 2001 Jul 16;194(2):113-26.
Perlman H, Pagliari LJ, Liu H, Koch AE, Haines GK 3rd, Pope RM.
Rheumatoid arthritis synovial macrophages express the Fas-associated death
domain-like interleukin-1beta-converting enzyme-inhibitory protein and are
refractory to Fas-mediated apoptosis.
Arthritis Rheum. 2001 Jan;44(1):21-30.
Georganas C, Liu H, Perlman H, Hoffmann A, Thimmapaya B, Pope RM.
Regulation of IL-6 and IL-8 expression in rheumatoid arthritis synovial fibroblasts:
the dominant role for NF-kappa B but not C/EBP beta or c-Jun.
J Immunol. 2000 Dec 15;165(12):7199-206.
Pagliari LJ, Perlman H, Liu H, Pope RM.
Macrophages require constitutive NF-kappaB activation to maintain A1 expression
and mitochondrial homeostasis.
Mol Cell Biol. 2000 Dec;20(23):8855-65.
Perlman H, Georganas C, Pagliari LJ, Koch AE, Haines K 3rd, Pope RM.
Bcl-2 expression in synovial fibroblasts is essential for maintaining mitochondrial
homeostasis and cell viability.
J Immunol. 2000 May 15;164(10):5227-35.
Perlman H, Sata M, Krasinski K, Dorai T, Buttyan R, Walsh K.
Adenovirus-encoded hammerhead ribozyme to Bcl-2 inhibits neointimal hyperplasia
and induces vascular smooth muscle cell apoptosis.
Cardiovasc Res. 2000 Feb;45(3):570-8.
Perlman H, Pagliari LJ, Georganas C, Mano T, Walsh K, Pope RM.
FLICE-inhibitory protein expression during macrophage differentiation confers
resistance to fas-mediated apoptosis.
J Exp Med. 1999 Dec 6;190(11):1679-88.
Perlman H, Luo Z, Krasinski K, Le Roux A, Mahfoudi A, Smith RC, Branellec
D, Walsh K.
Adenovirus-mediated delivery of the Gax transcription factor to rat carotid
arteries inhibits smooth muscle proliferation and induces apoptosis.
Gene Ther. 1999 May;6(5):758-63.
Perlman H, Zhang X, Chen MW, Walsh K, Buttyan R. An elevated bax/bcl-2 ratio
corresponds with the onset of prostate epithelial cell apoptosis. Cell Death
Differ. 1999 Jan;6(1):48-54.
Perlman H, Sata M, Le Roux A, Sedlak TW, Branellec D, Walsh K. Bax-mediated
cell death by the Gax homeoprotein requires mitogen activation but is independent
of cell cycle activity. EMBO J. 1998 Jul 1;17(13):3576-86.
Perlman H, Suzuki E, Simonson M, Smith RC, Walsh K. GATA-6 induces p21(Cip1)
expression and G1 cell cycle arrest. J Biol Chem. 1998 May 29;273(22):13713-8.
Walsh K, Perlman H. Cell cycle exit upon myogenic differentiation. Curr Opin
Genet Dev. 1997 Oct;7(5):597-602. Review.