John E. Tavis, Ph.D.
Associate Professor

Ph.D., The Pennsylvania State University, 1990
tavisje@slu.edu

Recent references:

Brodsky LI, Wahed AS, Li J, Tavis JE, Tsukahara T, Taylor MW.
A novel unsupervised method to identify genes important in the anti-viral
response: application to interferon/ribavirin in hepatitis C patients.
PLoS ONE. 2006 Jul 4;1:e584.
Pubmed Abstract link: 17589564

Donlin MJ, Cannon NA, Yao E, Li J, Wahed A, Taylor MW, Belle SH, Di Bisceglie
AM, Aurora R, Tavis JE; Virahep-C Study Group.
Pretreatment sequence diversity differences in the full-length hepatitis C virus
open reading frame correlate with early response to therapy.
J Virol. 2007 Aug;81(15):8211-24.
Pubmed Abstract link: 17522222

Taylor MW, Tsukahara T, Brodsky L, Schaley J, Sanda C, Stephens MJ, McClintick
JN, Edenberg HJ, Li L, Tavis JE, Howell C, Belle SH.
Changes in gene expression during pegylated interferon and ribavirin therapy of
chronic hepatitis C virus distinguish responders from nonresponders to antiviral
therapy.
J Virol. 2007 Apr;81(7):3391-401.
Pubmed Abstract link: 17267482

Zhou D, Fan X, Tan D, Xu Y, Tavis JE, Di Bisceglie AM.
Separation of near full-length hepatitis C virus quasispecies variants from a
complex population.
J Virol Methods. 2007 May;141(2):220-4.
Pubmed Abstract link: 17208310

Conjeevaram HS, Kleiner DE, Everhart JE, Hoofnagle JH, Zacks S, Afdhal NH,
Wahed AS; Virahep-C Study Group.
Race, insulin resistance and hepatic steatosis in chronic hepatitis C.
Hepatology. 2007 Jan;45(1):80-7.
Pubmed Abstract link: 17187406

Badtke MP, Cao F, Tavis JE.
Combining genetic and biochemical approaches to identify functional molecular
contact points.
Biol Proced Online. 2006;8:77-86.
Pubmed Abstract link: 17033698

Zhang Z, Tavis JE.
The duck hepatitis B virus reverse transcriptase functions as a full-length
monomer.
J Biol Chem. 2006 Nov 24;281(47):35794-801.
Pubmed Abstract link: 17005569

Cao F, Tavis JE.
Suppression of mRNA accumulation by the duck hepatitis B virus reverse
transcriptase.
Virology. 2006 Jul 5;350(2):475-83.
Pubmed Abstract link: 16563457

Yao E, Tavis JE; Virahep-C Study Group.
A general method for nested RT-PCR amplification and sequencing the complete HCV
genotype 1 open reading frame.
Virol J. 2005 Dec 1;2:88.
Pubmed Abstract link: 16321149

Cannon, N., Metzger, L.M., Donlin, M.J., Lyra, A., Yao, E., Di Bisceglie, A., and Tavis,J.E.
Genetic and biochemical evidence for action of ribavirin through the hepatitis C virus RNA polymerase in humans.
Manuscript submitted.

Tester, I., Smyk-Pearson, S., Wang, P., Wertheimer, A., Yao, E., Lewinsohn, D.M., Tavis, J.E., and Rosen, H.R.
Immune evasion versus recovery following acute hepatitis C virus infection from a shared source.
J. Exp. Med. 2005. 201:1725-1731.

Cao, F., Badtke, M.P., Adeyemo, B., Metzger, L.M., Yao, E., and Gong, Y, and Tavis, J.E.
Identification of an essential molecular contact point on the duck hepatitis B virus reverse transcriptase.
J. Virol. 2005. 79:10164-10170.

Yao, E., and Tavis, J.E.
A general method for nested RT-PCR amplification and sequencing the complete HCV genotype 1 open reading frame. Virology J.2005. 2:88.

Geiss BJ, Cano GL, Tavis JE, Morrison LA.
Herpes simplex virus 2 VP22 phosphorylation induced by cellular and viral kinases does not influence intracellular localization.
Virology. 2004 Dec 5;330(1):74-81.

Cao F, Tavis JE.
Detection and characterization of cytoplasmic hepatitis B virus reverse transcriptase.
J Gen Virol. 2004 Nov;85(Pt 11):3353-60.

Sen N, Cao F, Tavis JE.
Translation of duck hepatitis B virus reverse transcriptase by ribosomal shunting.
J Virol. 2004 Nov;78(21):11751-7.

Yao E, Tavis JE.
Localization of duck hepatitis B virus polymerase within cells.
Methods Mol. Med. 2004;95:281-93.

Yao E, Schaller H, Tavis JE.
The duck hepatitis B virus polymerase and core proteins accumulate in different patterns from their common mRNA.
Virology. 2003 Jun 20;311(1):81-8.

Yao E, Tavis JE.
Kinetics of synthesis and turnover of the duck hepatitis B virus reverse transcriptase.
J Biol Chem. 2003 Jan 10;278(2):1201-5.

Geiss BJ, Tavis JE, Metzger LM, Leib DA, Morrison LA.
Temporal regulation of herpes simplex virus type 2 VP22 expression and phosphorylation.
J Virol. 2001 Nov;75(22):10721-9.

Gong Y, Yao E, Tavis JE.
Evidence that the RNAseH activity of the duck hepatitis B virus is unable to act on exogenous substrates.
BMC Microbiol. 2001;1(1):12.

Yao E, Gong Y, Chen N, Tavis JE.
The majority of duck hepatitis B virus reverse transcriptase in cells is nonencapsidated and is bound to a cytoplasmic structure.
J Virol. 2000 Sep;74(18):8648-57.

Gong Y, Yao E, Stevens M, Tavis JE.
Evidence that the first strand-transfer reaction of duck hepatitis B virus reverse transcription requires the polymerase and that strand transfer is not needed for the switch of the polymerase to the elongation mode of DNA synthesis.
J Gen Virol. 2000 Aug;81(Pt 8):2059-65.

Tavis JE, Massey B, Gong Y.
The duck hepatitis B virus polymerase is activated by its RNA packaging signal, epsilon.
J Virol. 1998 Jul;72(7):5789-96.

Wei Y, Tavis JE, Ganem D.
Relationship between viral DNA synthesis and virion envelopment in hepatitis B viruses.
J Virol. 1996 Sep;70(9):6455-8.

Tavis JE, Ganem D.
Evidence for activation of the hepatitis B virus polymerase by binding of its RNA template.
J Virol. 1996 Sep;70(9):5741-50.

Gerelsaikhan T, Tavis JE, Bruss V.
Hepatitis B virus nucleocapsid envelopment does not occur without genomic DNA synthesis.
J Virol. 1996 Jul;70(7):4269-74.