Recent publications:
Tollefson AE, Kuppuswamy M, Shashkova EV, Doronin K, Wold
WS.
Preparation and titration of CsCl-banded adenovirus stocks.
Methods Mol Med. 2007;130:223-35.
Pubmed Abstract link: 17401177
Thomas MA, Lichtenstein DL, Krajcsi P, Wold WS.
A real-time PCR method to rapidly titer adenovirus stocks.
Methods Mol Med. 2007;130:185-92.
Pubmed Abstract link: 17401173
Chambers TJ, Droll DA, Jiang X, Wold WS, Nickells JA.
JE Nakayama/JE SA14-14-2 virus structural region intertypic viruses: Biological
properties in the mouse model of neuroinvasive disease.
Virology. 2007 May 21.
Pubmed Abstract link: 17521693
Thomas MA, Spencer JF, Wold WS.
Use of the Syrian hamster as an animal model for oncolytic adenovirus vectors.
Methods Mol Med. 2007;130:169-83.
Pubmed Abstract link: 17401172
Toth K, Spencer JF, Wold WS.
Immunocompetent, semi-permissive cotton rat tumor model for the evaluation
of
oncolytic adenoviruses.
Methods Mol Med. 2007;130:157-68.
Pubmed Abstract link: 17401171
Shashkova EV, Spencer JF, Wold WS, Doronin K.
Targeting Interferon-alpha Increases Antitumor Efficacy and Reduces
Hepatotoxicity of E1A-mutated Spread-enhanced Oncolytic Adenovirus.
Mol Ther. 2007 Mar;15(3):598-607.
Pubmed Abstract link: 17191072
Chambers TJ, Jiang X, Droll DA, Liang Y, Wold WS, Nickells
J.
Chimeric Japanese encephalitis virus/dengue 2 virus infectious clone: biological
properties, immunogenicity and protection against dengue encephalitis in mice.
J Gen Virol. 2006 Nov;87(Pt 11):3131-40.
Pubmed Abstract link: 17030845
Thomas MA, Spencer JF, La Regina MC, Dhar D, Tollefson AE,
Toth K, Wold WS.
Syrian hamster as a permissive immunocompetent animal model for the study
of oncolytic adenovirus vectors.
Cancer Res. 2006 Feb 1;66(3):1270-6.
Pubmed Abstract link: 16452178
Kanj SS, Dandashi N, El-Hed A, Harik H, Maalouf M, Kozhaya
L, Mousallem T,
Tollefson AE, Wold WS, Chalfant CE, Dbaibo GS.
Ceramide regulates SR protein phosphorylation during adenoviral infection.
Virology. 2006 Feb 5;345(1):280-9.
Pubmed Abstract link: 16271740
Toth, K., Doronin, K., Kuppuswamy, M., Ward, P., Tollefson,
A.E., and Wold, W.S.M.
Adenovirus immunoregulatory E3 proteins prolong transplants of human cells
in immunocompetent mice.
Virus Res. 2005 108 149-159.
Toth, K., Spencer, J.F., Tollefson, A.E., Kuppuswamy, M.,
Doronin, K., Lichtenstein, D.L., La Regina, M.C., Prince, G.A., and Wold,
W.S.M. Cotton rat tumor model for the evaluation of oncolytic adenoviruses.
Hum. Gene Ther. 2005 16, 139-146.
Kuppuswamy, M., Spencer, J.F., Doronin, K., Tollefson, A.E.,
Wold, W.S.M., and Toth, K.
Oncolytic adenovirus vector that overproduces the cytolytic ADP protein and
replicates selectively in tumor cells due to regulation of E4 gene expression
by the hTERT promoter.
Gene Therapy, 2005 12, 1608-1617.
Lichtenstein, D.L. and Wold, W.S.M.
Experimental infections of humans with wild-type adenoviruses and with replication-competent
adenovirus vectors: replication, safety, and transmission.
Cancer Gene Therapy, 2004 11, 819-829.
Lichtenstein DL, Doronin K, Toth K, Kuppuswamy M,
Wold WS, Tollefson AE.
Adenovirus E3-6.7K protein is required in conjunction with the E3-RID protein
complex for the internalization and degradation of TRAIL receptor 2.
J Virol. 2004 Nov;78(22):12297-307.
Lichtenstein DL, Wold WS.
Experimental infections of humans with wild-type adenoviruses and with replication-competent
adenovirus vectors: replication, safety, and transmission.
Cancer Gene Ther. 2004 Dec;11(12):819-29.
Toth K, Djeha H, Ying B, Tollefson AE, Kuppuswamy M, Doronin K, Krajcsi P,
Lipinski K, Wrighton CJ, Wold WS.
An oncolytic adenovirus vector combining enhanced cell-to-cell spreading,
mediated by the ADP cytolytic protein, with selective replication in cancer
cells with deregulated wnt signaling.
Cancer Res. 2004 May 15;64(10):3638-44.
Lichtenstein DL, Toth K, Doronin K, Tollefson AE, Wold WS.
Functions and mechanisms of action of the adenovirus E3 proteins. Int Rev
Immunol. 2004 Jan-Apr;23(1-2):75-111. Review.
Zanardi TA, Yei S, Lichtenstein DL, Tollefson AE, Wold WS.
Distinct domains in the adenovirus E3 RIDalpha protein are required for degradation
of Fas and the epidermal growth factor receptor.
J Virol. 2003 Nov;77(21):11685-96.
Ying B, Wold WS.
Adenovirus ADP protein (E3-11.6K), which is required for efficient cell lysis
and virus release, interacts with human MAD2B.
Virology. 2003 Aug 15;313(1):224-34.
Tarakanova VL, Wold WS.
Transforming growth factor beta1 receptor II is downregulated by E1A in adenovirus-infected
cells.
J Virol. 2003 Sep;77(17):9324-36.
Tollefson AE, Scaria A, Ying B, Wold WS.
Mutations within the ADP (E3-11.6K) protein alter processing and localization
of ADP and the kinetics of cell lysis of adenovirus-infected cells.
J Virol. 2003 Jul;77(14):7764-78.
Toth K, Doronin K, Tollefson AE, Wold WS.
A multitasking oncolytic adenovirus vector.
Mol Ther. 2003 Apr;7(4):435-7.
Toth K, Tarakanova V, Doronin K, Ward P, Kuppuswamy M, Locke JE, Dawson JE,
Kim HJ, Wold WS.
Radiation increases the activity of oncolytic adenovirus cancer gene therapy
vectors that overexpress the ADP (E3-11.6K) protein.
Cancer Gene Ther. 2003 Mar;10(3):193-200.
Doronin K, Toth K, Kuppuswamy M, Krajcsi P, Tollefson AE, Wold WS.
Overexpression of the ADP (E3-11.6K) protein increases cell lysis and spread
of adenovirus.
Virology. 2003 Jan 20;305(2):378-87.
Lichtenstein DL, Krajcsi P, Esteban DJ, Tollefson AE, Wold WS.
Adenovirus RIDbeta subunit contains a tyrosine residue that is critical for
RID-mediated receptor internalization and inhibition of Fas- and TRAIL-induced
apoptosis.
J Virol. 2002 Nov;76(22):11329-42.
Kladney RD, Tollefson AE, Wold WS, Fimmel CJ.
Upregulation of the Golgi protein GP73 by adenovirus infection requires the
E1A CtBP interaction domain.
Virology. 2002 Sep 30;301(2):236-46.
Habib NA, Mitry R, Seth P, Kuppuswamy M, Doronin K, Toth K, Krajcsi P, Tollefson
AE, Wold WS.
Adenovirus replication-competent vectors (KD1, KD3) complement the cytotoxicity
and transgene expression from replication-defective vectors (Ad-GFP, Ad-Luc).
Cancer Gene Ther. 2002 Aug;9(8):651-4.
Toth K, Wold WS.
HEK? No!
Mol Ther. 2002 Jun;5(6):654.
Hawkins LK, Wold WS.
A 20,500-Dalton protein is coded by region E3 of subgroup B but not subgroup
C human adenoviruses.
Virology. 1995 Apr 1;208(1):226-33.
Tollefson AE, Toth K, Doronin K, Kuppuswamy M, Doronina OA, Lichtenstein DL,
Hermiston TW, Smith CA, Wold WS.
Inhibition of TRAIL-induced apoptosis and forced internalization of TRAIL
receptor 1 by adenovirus proteins.
J Virol. 2001 Oct;75(19):8875-87.
Johnstone RW, Gerber M, Landewe T, Tollefson A, Wold WS, Shilatifard A.
Functional analysis of the leukemia protein ELL: evidence for a role in the
regulation of cell growth and survival.
Mol Cell Biol. 2001 Mar;21(5):1672-81.
Doronin K, Kuppuswamy M, Toth K, Tollefson AE, Krajcsi P, Krougliak V, Wold
WS.
Tissue-specific, tumor-selective, replication-competent adenovirus vector
for cancer gene therapy.
J Virol. 2001 Apr;75(7):3314-24.
Li Y, Wold WS.
Identification and characterization of a 30K protein (Ad4E3-30K) encoded by
the E3 region of human adenovirus type 4.
Virology. 2000 Jul 20;273(1):127-38.
Doronin K, Toth K, Kuppuswamy M, Ward P, Tollefson AE, Wold WS.
Tumor-specific, replication-competent adenovirus vectors overexpressing the
adenovirus death protein.
J Virol. 2000 Jul;74(13):6147-55.
Wold WS, Doronin K, Toth K, Kuppuswamy M, Lichtenstein DL, Tollefson AE.
Immune responses to adenoviruses: viral evasion mechanisms and their implications
for the clinic.
Curr Opin Immunol. 1999 Aug;11(4):380-6. Review.
Harrod KS, Hermiston TW, Trapnell BC, Wold WS, Whitsett JA.
Lung-specific expression of adenovirus E3-14.7K in transgenic mice attenuates
adenoviral vector-mediated lung inflammation and enhances transgene expression.
Hum Gene Ther. 1998 Sep 1;9(13):1885-98.
Krajcsi P, Wold WS.
Inhibition of tumor necrosis factor and interferon triggered responses by
DNA viruses.
Semin Cell Dev Biol. 1998 Jun;9(3):351-8. Review.
Krajcsi P, Wold WS.
Viral proteins that regulate cellular signalling.
J Gen Virol. 1998 Jun;79 ( Pt 6):1323-35. Review.
Tollefson AE, Hermiston TW, Lichtenstein DL, Colle CF, Tripp RA, Dimitrov
T, Toth K, Wells CE, Doherty PC, Wold WS.
Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells.
Nature. 1998 Apr 16;392(6677):726-30.
Dimitrov T, Krajcsi P, Hermiston TW, Tollefson AE, Hannink M, Wold WS.
Adenovirus E3-10.4K/14.5K protein complex inhibits tumor necrosis factor-induced
translocation of cytosolic phospholipase A2 to membranes.
J Virol. 1997 Apr;71(4):2830-7.