News

Katie Stockstill, graduate student in Dr. Salvemini's laboratory, was awarded the American Pain Society Young Investigator Travel Award  to attend the the Annual Scientific Meeting of the American Pain Society, April 30- May 3, 2014 in Tampa, FL. Katie will be presenting her poster entitled "Bortezomib-induced neuropathic pain is blocked and reversed by blocking the the S1P/S1PR1 axis" on Thursday, May 1, 2014 as a part of this Annual Scientific Meeting.
Kali Janes, post doctoral fellow in Dr. Salvemini's laboratory, was awarded the American Pain Society Young Investigator Travel Award to attend the Annual Scientific Meeting of the American Pain Society, April 30-May 3, 2014 in Tampa, FL. Kali will be presenting her poster entitled “The role of peroxynitrite in peripheral nerve sensory axon mitotoxicity during chemotherapy-induced neuropathic pain” on Friday, May 2, 2014 as a part of the Annual Scientific Meeting.
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Awards and Recognitions

Grant Awards
Click on the names bellow to see more information about these grants.

Grants

 

Daniela Salvemini, Ph.D. was awarded a grant from NIH/NIDA for 5 years for $1,771,000 for research entitled, “Role of peroxynitrite in morphine hyperalgesia and tolerance”. Opioid drugs such as morphine are the most effective analgesics for treating acute/severe chronic pain, but their pain-relieving action is often diminished during chronic administration, necessitating dose escalation that reduces quality of life for the patient.  This work will help elucidate the mechanisms and pathways in which the toxic by-product of superoxide and nitric oxide, peroxynitrite, negatively impacts opioid-induced analgesia. The outcome of this research will provide a novel mechanistic rationale for development of potent peroxynitrite-targeted therapies to maintain adequate pain relief during repetitive dosing for chronic pain, without engendering tolerance or unacceptable side-effects, thus addressing a large unmet medical need with major socioeconomic consequences.

 

Daniel Scott Zahm, PhD Click Here to learn more

Daniel Scott Zahm, Ph.D. was awarded a grant from NIH/NINDS for 5 years for $1,442,174. The proposed research entitled, “Convergent Versus Parallel Striatal Afferents,” addresses a brain system concerned with mechanisms that underlie decision-making by investigating its neuroanatomical relationships, the behavioral correlates of stimulating and inactivating it and the mechanisms by which it influences the reward system. The results should lead to better means to address how brain mechanisms subserving decision-making are affected by stress, alcohol and drugs, and, hopefully, to improved approaches to countering maladaptive decision-making, which, to a significant extent, underlies many of the chronic problems experienced by American individuals, families and society, including various forms of addiction and the seemingly inevitable cascades of relapse. 

Mary Ellsworth Click Here to learn more

Mary Ellsworth, Randy Sprague, Alan Stephenson and Christopher Ellis were awarded an Exploratory Program in Systems Biology (R33) grant. The regulation of oxygen supply to match oxygen demand in skeletal muscle is a fundamental physiological process, yet because of its complexity, attempts to describe it have been generally inadequate. It has become increasingly obvious that because processes like these cannot be understood merely by reducing them to their component parts, they must be studied as intact, functioning systems using a systems biology approach with computational modeling. In this proposal we use a systems biology approach to determine whether the release of ATP from red blood cells in response to metabolic need is responsible for local regulation of oxygen supply within skeletal muscle and test the predictions of the model by examining it using a system (type 2 diabetes) in which there is a defect in that regulatory system, i.e., ATP release from RBCs of type 2 diabetics is compromised. 

Awards

Willis K. Samson PhD DSc has been selected by the American Physiological Society to be the new Editor-in-Chief of the American Journal of Physiology: Regulatory, Integrative and Comparative Physiology (http://www.the-aps.org/mm/Publications/Journals/AJP-Regu). 

Willis K. Samson PhD DSc has been appointed Head of Faculty in Diabetes & Endocrinology for F1000 Prime, Faculty of 1000 in Biology and Medicine (http://f1000.com/prime/thefaculty/member/1019073880549712).

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