David Wilson received 3rd Place for his poster presentation at the Nineteenth Annual Graduate Research Symposium at Saint Louis University on April 26, 2013
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Pharmacological & Physiological Science
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Awards and Recognitions
Click on the names bellow to see more information about these grants.
Dr. Daniela Salvemini was awarded a NIH/NIDA R21 grant entitled "Role of ceramide in morphine hyperalgesia and tolerance" effective September 30th, 2008 for 2 years. The award is for $392.325.
The objectives of this exploratory grant proposal are to elucidate the roles of sphingolipids in the development of analgesic tolerance following repeated use of opiates such as morphine. The broader objectives are to determine whether pharmacological manipulation of the pathways leading to the biosynthesis of various sphingolipids such as ceramide offer an attractive therapeutic target for pain management.
Daniela Salvemini, Ph.D. Click Here to learn more
Daniela Salvemini, Ph.D. was awarded a grant from NIH/NIDA for 5 years for $1,771,000 for research entitled, “Role of peroxynitrite in morphine hyperalgesia and tolerance”. Opioid drugs such as morphine are the most effective analgesics for treating acute/severe chronic pain, but their pain-relieving action is often diminished during chronic administration, necessitating dose escalation that reduces quality of life for the patient. This work will help elucidate the mechanisms and pathways in which the toxic by-product of superoxide and nitric oxide, peroxynitrite, negatively impacts opioid-induced analgesia. The outcome of this research will provide a novel mechanistic rationale for development of potent peroxynitrite-targeted therapies to maintain adequate pain relief during repetitive dosing for chronic pain, without engendering tolerance or unacceptable side-effects, thus addressing a large unmet medical need with major socioeconomic consequences.
Daniel Scott Zahm, PhD Click Here to learn more
Daniel Scott Zahm, Ph.D. was awarded a grant from NIH/NINDS for 5 years for $1,442,174. The proposed research entitled, “Convergent Versus Parallel Striatal Afferents,” addresses a brain system concerned with mechanisms that underlie decision-making by investigating its neuroanatomical relationships, the behavioral correlates of stimulating and inactivating it and the mechanisms by which it influences the reward system. The results should lead to better means to address how brain mechanisms subserving decision-making are affected by stress, alcohol and drugs, and, hopefully, to improved approaches to countering maladaptive decision-making, which, to a significant extent, underlies many of the chronic problems experienced by American individuals, families and society, including various forms of addiction and the seemingly inevitable cascades of relapse.
Mary Ellsworth Click Here to learn more
Mary Ellsworth, Randy Sprague, Alan Stephenson and Christopher Ellis were awarded an Exploratory Program in Systems Biology (R33) grant. The regulation of oxygen supply to match oxygen demand in skeletal muscle is a fundamental physiological process, yet because of its complexity, attempts to describe it have been generally inadequate. It has become increasingly obvious that because processes like these cannot be understood merely by reducing them to their component parts, they must be studied as intact, functioning systems using a systems biology approach with computational modeling. In this proposal we use a systems biology approach to determine whether the release of ATP from red blood cells in response to metabolic need is responsible for local regulation of oxygen supply within skeletal muscle and test the predictions of the model by examining it using a system (type 2 diabetes) in which there is a defect in that regulatory system, i.e., ATP release from RBCs of type 2 diabetics is compromised.
Johnnie Moore was awarded a Minority Biophysicists Travel Grant to the joint 52nd Annual Meeting of the Biophysical Society and IRPAB International Biophysics Congress that will be held February 2-6, 2008, in Long Beach, California.
Madelyn Hanson is the recipient of the Microcirculatory Society's 2008 Zweifach Student Travel Award.
Dr. Willis K. Samson has been invited to present “10 years of Orexins - Physiology and Pathophysiology” on Wednesday and Thursday, 13th-14th of August, 2008 at the Kastelli Research Center, Oulu University, Oulu, Finland. The symposium will be sponsored in part as an Acta Physiologica International Symposium.
Dr. Willis K. Samson has been invited to speak at the International Symposium on "Neuroendocrine Control of Food Intake and Body Fluid Homeostasis" at the XXIII Annual Meeting of the Brazilian Federation of Biological Sciences (FESBE) in Sao Paulo, Brazil, August 20-23, 2008. The title of Dr. Samson's lecture will be "Bioinformatic Approaches to the Discovery of Novel Feeding Peptides."