Dr. Stein has accepted an NIH funded postdoctoral fellowship in the Department of Psychiatry and the Translational Neurosciences Program at the Perlman School of Medicine, University of Pennsylvania. Dr. Stein will be continuing her studies on the neuroendocrinology of energy balance in the laboratory of Dr. Matthew Hayes.
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Department of Pharmacological and Physiology
Room M 362 || 1402 South Grand Blvd
St. Louis, Missouri 63104
Daniel S. Zahm, Ph.D.
Pharmacological and Physiological Science
Saint Louis University School of Medicine
Department of Anatomy and Neurobiology
Saint Louis University School of Medicine
Departments of Neurology,
Neurosurgery and Otolaryngology,
University of Virginia School of Medicine,
Pennsylvania State University, 1982
The laboratory seeks to understand fundamental patterns of organization in the basal forebrain, how forebrain systems contribute to behavioral synthesis and brain development and what the vulnerabilities of different forebrain systems are in circumstances leading to neurodegeneration.
Honors & Awards
Leverhulme Visiting Professorship,
University of St. Andrews, St. Andrews,
Scotland, June-December, 2000
Forbairt Visiting Professorship,
Royal College of Surgeons and Trinity College,
Dublin, June - July, 1997
Convergent vs. Parallel Striatal Afferents
Editorial Boards: Neuroscience (1995-present); Journal of Comparative Neurology (2004-2007; 2012-2016); Journal of Chemical Neuroanatomy (2005-present); Brain Structure and Function (2006-present)
Society for Neuroscience
International Brain Research Organization
- Selected Papers from 101 (citations from GoogleScholar as of 3/07/2014):
Yetnikoff, L., Cheng, A., Lavezzi, H.N., Parsley, K.P., Zahm, D.S. (2015) Sources of input to the ventral tegmental area, rostromedial tegmental nucleus and lateral habenula compared: a study in rat. J Comp Neurol 523:2426-56. (cited by 0)
Lavezzi, H.N., Parsley, K.P., Zahm, D.S. (2015) Modulation of locomotor activation by the rostromedial tegmental nucleus. Neuropsychopharmacology 40:676-687. (cited by 5)
Yetnikoff, L., Lavezzi, H.N., Reichard R.A., Zahm, D.S. (2014) An update on the connections of the ventral mesencephalic dopaminergic complex. Neuroscience 282C:23-48. (cited by 35)
Zahm DS, Schwartz ZM, Lavezzi,HN, Yetnikoff L, Parsley KP (2014): Comparison of the locomotor activating effects of bucuculline infusions into the preoptic area and ventral pallidum. Brain Struct&Function (cited by 6).
Zahm DS, Parsley KP, Schwartz ZM, Cheng AY: Connections of the accumbal ‘hedonic hotspot’ of Pecina and Berridge with commentary on the transitional nature of basal forebrain’boundaries’. J. Comp. Neurol.521:50-68, 2013 (cited by 35).
St.Onge JR, Stopper CM, Zahm DS, Floresco SB: Separate neural circuits bias choice towards risky or certain options. J Neurosci, 32:2886-2899, 2012 (cited by 63).
Zahm DS, Cheng AY, Lee TJ, Ghobadi CW, Schwartz ZM, Geisler S, Parsely KP, Gruber C, Veh RW: Inputs to the midbrain dopaminergic complex in the rat, with emphasis on extended amygdala-recipient sectors. J Comp Neurol 519:3159-3188, 2011 (cited by 27).
Lavezzi HN, Parsley KP, Zahm DS: Mesopontine rostromedial tegmental nucleus neurons projecting to the dorsal raphe and pedunculopontine tegmental nucleus: psychostimulant-elicited Fos expression and collateralization. Brain Structure & Function 217:719-734, 2012 (cited by 18).
Lavezzi HN, Zahm DS: The mesopontine tegmental nucleu: an integrative modulator of the reward system. Basal Ganglia 1:191-200, 2011 (cited by 28) .
Zahm, D.S., Pharmacological approach to the treatment of addiction: persisting challenges. Missouri Medicine 107:276-280, 2010 (cited by 6).
Zahm, D.S., Becker M.L., Freiman A.J., Strauch S., DeGarmo B., Geisler S., Meredith G.E., and Marinelli M.: Fos after single and repeated self-administration of cocaine and saline in the rat: emphasis on the basal forebrain and recalibration of expression. Neuropsychopharmacology, 35:445-463, 2010 (cited by 42).
Jhou, TC., Geisler, S., Marinelli, M., and Zahm, D.S.: Medial tegmental nucleus: a mesopontine structure targeted by the lateral habenula that projects to the ventral tegmental area and substantia nigra compacta. J . Comp. Neurol. 513:566-596, 2009 (cited by 194).
Geisler, S., Marinelli, M., DeGarmo, B., Becker M.L., Freiman, A.J., Beales, M., Meredith, G.E., and D.S. Zahm: Prominent activation of brainstem and pallidal afferents of the ventral tegmental area by cocaine. Neuropsychopharmacology, 33:2688-2700, 2008 (52).
Zahm, D.S., Trimble, M.R.: The dopaminergic projection system, basal forebrain macrosystems, and conditioned stimuli. CNS Spectrums 13:887-892, 2008 (cited by 17).
Geisler, S., Derst, C., Veh, R.W. and D.S. Zahm: Glutamatergic afferents of the ventral tegmental area in the rat. J. Neurosci. 27:5730-5743, 2007 (cited by 281).
Zahm, D.S. The evolving theory of basal forebrain "functional anatomical macrosystems. Neurosci. Biobehav. Rev., 30:148-172, 2006 (cited by 91).
Reynolds, S.M., and D.S. Zahm: Specificity in the projections of prefrontal and insular cortex to ventral striatopallidum and extended amygdala. J. Neurosci. 25:11757-11767, 2005 (cited by 130).
Geisler, S., and D.S. Zahm: Afferents of the ventral tegmental area in the rat - anatomical substratum for integrative functions. J. Comp. Neurol. 490:270-294, 2005 (cited by 255).
Zahm, D.S.: An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens. Neurosci. Biobehav. Rev. 24:85-105, 2000 (cited by 402).
Brog, J.S., A. Salypongse, A.Y. Deutch and D.S. Zahm: The patterns of afferent innervation of the core and shell in the "accumbens" part of the rat ventral striatum: Immunohistochemical detection of retrogradely transported Fluoro-Gold. J. Comp. Neurol., 338:255-278, 1993 (cited by 852).
Zahm, D.S. and J.S. Brog: Commentary: On the significance of the core-shell boundary in the rat nucleus accumbens. Neuroscience 50:751-767, 1992 (cited by 850).
Selected Book Chapters (from 11):
Zahm, D.S.: Accumbens in a Functional-Anatomical Systes Context: In: (David H, ed.) The nucleus accumbens: neurotransmitters and related behaviours, Transworld Research Network-Research Signpost, Kerala, India, pgs. 1-37, 2008.
Zahm, D.S., and L. Heimer: Limbic System. In: (Binder MD, Hirokawa N and Windhorst U, eds.) Encyclopedia of Neuroscience, Vol. 3 H-M, Springer, pgs. 2157-2161, 2009.
Zahm, D.S.: Chapter 25. Rostromedial tegmental nucleus: connections with the basal ganglia. 2016. In: (Steiner H, Tseng, K-Y) Handbook of Basal Ganglia Structure and Function, Second Edition. Elsevier, Amsterdam. (in press, to be released Sept 2016)
Heimer, L., Van Hoesen, G.W., Trimble, M., Zahm, D.S. Anatomy of Neuropsychiatry. The New Anatomy of the Basal Forebrain and its Implications for Neuropsychiatric Illness. Elsevier, Amsterdam. 2008.