pharmphys

Sensorimotor information processing from visual and vestibular inputs that control eye movements.

Cell-cycle regulation and intracellular signal transduction mechanisms.

Transcriptional reegulation by coactivators and nuclear receptors.

Neurotransmitter receptors; molecular biology and developmental regulation of glutamate and P2X receptors.

Receptor and voltage gated ion channels.

Microcirculatory hemodynamics and oxygen transport; role of the red blood cell as a vascular regulator; cardiovascular science.

Structural mechanisms underlying modulation of KirBac1.1 channel activity by membrane lipids and protons.

Cellular and molecular mechanisms of synaptic vesicle release; calcium channels.

Autonomic pharmacology and physiology; central cardiovascular regulation; electrophysiology; effects of cocaine, stress and endotoxemia.

Pulmonary physiology; acute lung injury and the immunophysiology of sepsis.

Neural information processing; sensory neural coding; psychophysics; taste; orosensory properties of alcohol.

Cardiovascular regulation; molecular and cellular mechanisms responsible for myocardial and hepatic dysfunction in septic shock.

Vascular control mechanisms; endothelial mediators; sympathetic neurotransmission.

Neurotransmitter signaling pathways in stress and aging.

Neural integration of somatoautonomic reflexes: cardiorespiratory changes in the diving response and pain

Role of reactive oxygen and nitrogen  species and lipid mediators in acute and chronic pain and in the development of opiate antinociceptive tolerance.

Neuropeptides and the control of cardiovascular function and stress hormone secretion

The role of the red blood cell as a determinant of vascular resistance.

Vascular control mechanisms: eicosanoids, pulmonary & cardiovascular science.

Biochemical and molecular neuropharmcology and neuroscience; molecular biology and development regulation of purinergic receptors; development of sensory neurons in zeberafish.

Biochemical neuropharmacology; monoamine and peptide regulation; autonomic pharmacology and cardiovascular science.

Neuroanatomical and functional organization of basal forebrain; neurodegeneration, role of peptides in psychostimulant and opioid actions.

Transport of peptides and proteins across the blood-brain barrier.

The over-arching goal of my investigations is to understand the extrinsic cues and the intrinsic regulatory mechanisms of extraocular muscle (EOM) and specifically the mechanism that drives the diversity of the EOM phenotype.

Acute lung injury; septic shock; immunophysiology of sepsis; cytokine biology; oxygen-dependent gene regulation; ischemia/reperfusion injury; redox-sensitive transcriptional activation.

Antiepileptic drug development and use; animal models of epilepsy; molecular biology of brain injury and drug effects.

Exercise physiology.

Coronary physiology; endothelial control of coronary blood flow; exercise physiology; pathophysiology of heart failure.

Analytical and forensic toxicology