News

Nickolas SteinauerNickolas Steinauer, an MD/PHD student in Dr. Jinsong Zhang's lab, won a Travel Award to attend the 2016 ASH Meeting on Hematologic Malignancies held in Chicago this September.

Nick's abstract was chosen as one of the top 6 abstracts for oral presentation at the meeting. He is currently supported by the T32 training grant in the Department. Congratulations, Nick!
ASH Meeting September 2016
Lauren Stein, a graduate student in the Yosten/Samson lab, received her doctorate at the SLU 2016 Graduate Programs commencement exercises May 12th. In April Dr. Stein received the Research Recognition Award from the Endocrinology and Metabolism Section of the American Physiological Society for her work identifying the receptor of the novel peptide hormone, Phoenixin, which was discovered by Drs. Yosten and Samson in 2013.

Dr. Stein has accepted an NIH funded postdoctoral fellowship in the Department of Psychiatry and the Translational Neurosciences Program at the Perlman School of Medicine, University of Pennsylvania. Dr. Stein will be continuing her studies on  the neuroendocrinology of energy balance in the laboratory of Dr. Matthew Hayes.
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Department of Pharmacological and Physiology
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Phone: 314-977-6400
Fax: 314-977-6410
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L. James Willmore, M.D.

Professor
Departments of Neurology and Pharmacological and Physiological Science
M.D., Saint Louis University School of Medicine, 1968;
previously on the staffs of University of Florida and University of Texas, Houston

Email willmore@slu.edu


RESEARCH SUMMARY

Epilepsy in humans develops after head trauma. Epileptogenesis from such trauma in humans remains an enigma. Components of blood, especially aqueous solutions of ferric salts, injected into amygdalar regions of rats cause the development of chronic, recurrent seizures in the pattern of kindling. Mechanisms of initiation of chronic seizures in this model have emphasized the development of regions of injury caused by initiation reactions of lipid peroxidation. Molecular regulation of transporters for glutamate and GABA appears to be altered in this epilepsy model and in both kindled and kainate-induced animals. Work underway examines the effect of various drugs to measure any molecular neuropharmacological effect of the antiepileptic medications. In addition, this laboratory is interested in adverse effects of antiepileptic drugs.


SELECTED PUBLICATIONS

  1. Ueda, Y., Willmore, L.J., Triggs, W.J. Amygdalar injection of FeCl3 causes spontaneous recurrent seizures Experimental Neurology 153: 123-127, 1998
  2. Doi, T., Ueda, Y., Tokumaru, J., Mitsuyama, Y., Willmore, L.J. Sequential changes in glutamate transporter mRNA during Fe+++ induced epileptogenesis. Molecular Brain Research 75: 105-112, 2000
  3. Ueda, Y., Willmore, L.J. Sequential changes in glutamate transporter protein levels during Fe+++-induced epileptogenesis. Epilepsy Research 39: 201-219, 2000.
  4. Ueda, Y., Willmore, L.J. Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis. Experimental Brain Research. 133:334-339, 2000.

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