Nick's abstract was chosen as one of the top 6 abstracts for oral presentation at the meeting. He is currently supported by the T32 training grant in the Department. Congratulations, Nick!
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Department of Pharmacological and Physiology
Room M 362 || 1402 South Grand Blvd
St. Louis, Missouri 63104
L. James Willmore, M.D.
Departments of Neurology and Pharmacological and Physiological Science
M.D., Saint Louis University School of Medicine, 1968;
previously on the staffs of University of Florida and University of Texas, Houston
Epilepsy in humans develops after head trauma. Epileptogenesis from such trauma in humans remains an enigma. Components of blood, especially aqueous solutions of ferric salts, injected into amygdalar regions of rats cause the development of chronic, recurrent seizures in the pattern of kindling. Mechanisms of initiation of chronic seizures in this model have emphasized the development of regions of injury caused by initiation reactions of lipid peroxidation. Molecular regulation of transporters for glutamate and GABA appears to be altered in this epilepsy model and in both kindled and kainate-induced animals. Work underway examines the effect of various drugs to measure any molecular neuropharmacological effect of the antiepileptic medications. In addition, this laboratory is interested in adverse effects of antiepileptic drugs.
- Ueda, Y., Willmore, L.J., Triggs, W.J. Amygdalar injection of FeCl3 causes spontaneous recurrent seizures Experimental Neurology 153: 123-127, 1998
- Doi, T., Ueda, Y., Tokumaru, J., Mitsuyama, Y., Willmore, L.J. Sequential changes in glutamate transporter mRNA during Fe+++ induced epileptogenesis. Molecular Brain Research 75: 105-112, 2000
- Ueda, Y., Willmore, L.J. Sequential changes in glutamate transporter protein levels during Fe+++-induced epileptogenesis. Epilepsy Research 39: 201-219, 2000.
- Ueda, Y., Willmore, L.J. Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis. Experimental Brain Research. 133:334-339, 2000.